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Advanced Regenerative Medicine in Los Angeles

Surgery isn't always the right first step. Our regenerative medicine program uses your body's own healing biology (PRP and bone marrow aspirate concentrate) to support tissue healing and help preserve natural joints. Backed by orthopedic evidence, delivered honestly.

Advanced Regenerative Medicine at LAOSS orthopedic clinic in Los Angeles. Board-certified specialists, same-day appointments

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Board-certified surgeons and podiatrists across eight Los Angeles area neighborhoods.

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Conditions we treat with regenerative medicine

  • Chronic tendinopathy (tennis elbow, patellar, Achilles, rotator cuff)
  • Mild to moderate osteoarthritis of the knee, hip, or shoulder
  • Partial tendon or ligament tears that haven't healed with rest
  • Soft-tissue injuries from sports or overuse
  • Plateaued recovery after physical therapy or conservative care

What sets LAOSS apart

  • Straight talk on the evidence: what works, what's experimental
  • On-site imaging; ultrasound-guided injections for accuracy
  • Conservative-first care, biologics only when they fit your case
  • Board-certified specialists, not med-spa drop-ins

Key takeaways

  • Regenerative medicine is an umbrella term: PRP, BMAC (bone marrow aspirate concentrate), prolotherapy, and amniotic-derived products all fall under it.
  • PRP has decent evidence for some tendinopathies and mild knee OA. BMAC/'stem cell' therapies have more limited high-quality evidence and are generally not FDA-approved for these uses.
  • Most regenerative therapies are not covered by insurance and are paid out of pocket. We'll be upfront about cost before you commit.
  • Best candidates: adults ages 30 to 70 with chronic orthopedic pain who want to avoid or delay surgery after conservative care has plateaued.

What is regenerative medicine?

Regenerative medicine is an umbrella category of orthopedic treatments that use biologic material (your own platelets, growth factors, or bone marrow cells) to stimulate healing in damaged tissue. The goal is to help you delay or avoid surgery, preserve your native joint, and get back to activity.

The main therapies in this category are PRP (platelet-rich plasma), BMAC (bone marrow aspirate concentrate, sometimes marketed as "stem cell"), prolotherapy, and amniotic-derived products. They're most commonly used for chronic tendinopathy, mild-to-moderate osteoarthritis, partial tendon or ligament tears, and soft-tissue injuries that haven't responded to rest, PT, or activity modification.

We'll say this plainly: the evidence varies a lot by therapy and condition. PRP has reasonable evidence for tennis elbow, patellar tendinopathy, and mild knee OA. BMAC and "stem cell" therapies have more limited high-quality evidence in orthopedics today and are generally not FDA-approved for these uses. Most regenerative therapies are also not covered by insurance. Our job is to tell you when biologics are a sensible option for your case, and when they're not.

Watch: Stem Cell Therapy (Overview)

If you have an injury, or if you have tendons or ligaments that have become inflamed, stem cell therapy may help. It uses your body's own stem cells to help heal damage. It may help you avoid surgery.

Animations licensed from ViewMedica · Swarm Interactive
Illustration of a platelet-rich plasma (PRP) injection: concentrated platelets and growth factors delivered into an injured tendon or joint
Biologic injections deliver concentrated platelets, growth factors, or bone marrow cells directly to the injured tissue, typically under ultrasound guidance.
How it works

Inside a biologic injection.

PRP starts with a small blood draw: your blood is spun in a centrifuge to concentrate the platelets, which carry the growth factors that signal tissue repair. BMAC follows the same logic, but starts from a bone marrow aspirate. Either way, the prepared biologic is injected, usually under ultrasound guidance, into the injured tendon, ligament, or joint. The goal isn't a numbing effect; it's stimulating the body's own repair signal.

When biologics fit

Common reasons we use regenerative medicine.

Common symptoms

  • Chronic tendinopathy (tennis elbow, patellar tendon, Achilles)
  • Mild-to-moderate knee, hip, or shoulder osteoarthritis
  • Partial rotator cuff tears that haven't fully healed
  • Hamstring, hip flexor, or other soft-tissue strains
  • Plantar fasciitis that didn't respond to stretching and orthotics
  • Mild ligament sprains in active patients
  • Pain that has plateaued after a course of physical therapy
  • Conservative care that worked partially but not fully

Common causes

  • Overuse injuries from sports, work, or repetitive movement
  • Age-related joint and tendon wear-and-tear
  • Healing slowed by reduced blood flow to tendons or cartilage
  • Inflammation that has shifted from acute to chronic
  • A desire to avoid or delay surgery in a borderline-surgical case

What regenerative medicine can, and can't, do.

Regenerative medicine is best understood as a tool in the toolbox, not a miracle. For the right patient and the right condition, biologic injections can meaningfully reduce pain, improve function, and buy time before a more invasive procedure becomes necessary. For the wrong patient, they're an expensive intervention that won't move the needle.

The orthopedic literature today supports PRP as a reasonable option for mild to moderate knee osteoarthritis, lateral epicondylitis (tennis elbow), patellar tendinopathy, and select rotator cuff tendinopathy. The evidence is mixed but encouraging for plantar fasciitis and Achilles tendinopathy. The evidence is more limited (and the marketing more aggressive) for autologous stem cell or BMAC therapies in orthopedics. The FDA has been clear that most marketed "stem cell" treatments for joint pain have not been approved.

What this means for you: we'll evaluate your case, tell you which biologic (if any) has the best evidence for your condition, give you a realistic expectation of response rate, and walk through what the cost will be before you commit. If regenerative medicine isn't the right call, we'll say so.

Conservative care and regenerative options at LAOSS.

Almost every patient we see for chronic ortho pain has tried something already. Our job is to put the next step in context: conservative care if there's still runway there, biologic therapy when it fits, surgery only when the picture warrants it.

Conservative care
Step 1

Conservative care first

Most patients respond to a thoughtful conservative plan. We start here unless imaging or exam tells us otherwise.

  • Activity modification and load management
  • Targeted physical therapy with your in-network provider
  • NSAIDs or other anti-inflammatory medication
  • Bracing, taping, or ergonomic adjustments
  • Corticosteroid injection (judicious use)
  • Viscosupplementation (hyaluronic-acid gel) for knee OA
Surgical care
When needed

Regenerative options

When conservative care has plateaued and you want to avoid or delay surgery, biologics are worth a conversation.

  • PRP (platelet-rich plasma): strongest evidence for tendinopathy, mild knee OA
  • BMAC (bone marrow aspirate concentrate): emerging evidence, not FDA-approved for joint indications
  • Prolotherapy: irritant injection that may trigger a healing response
  • Amniotic-derived products: limited high-quality evidence
  • Ultrasound-guided delivery for accuracy when appropriate
  • Honest cost conversation before treatment: most are self-pay

Why experience matters.

Why experience matters

Biologic therapy is technique-dependent. Where you inject, how you prepare the sample, and whether the patient is the right candidate all change the outcome.

  • Accurate diagnosis from imaging and exam before any injection
  • Honest assessment of whether biologics fit your case
  • Ultrasound-guided technique when accuracy matters
  • Coordinated rehab so the biologic has a chance to work

The LAOSS approach

We move stepwise: least-invasive option first, escalate only when the evidence and the patient call for it.

  • Board-certified orthopedic specialists, not med-spa providers
  • Same-day imaging at most offices
  • Cost transparency before any self-pay treatment
  • We'll tell you when a biologic is the wrong tool for your case

Am I a candidate?

Regenerative medicine isn't for everyone, but if most of these describe you, it's worth a conversation.

You may be

You may be a candidate if

These signs typically point toward an in-person evaluation for biologic therapy.

  • Chronic tendon or joint pain lasting more than three months
  • Mild to moderate arthritis on imaging, not bone-on-bone
  • Partial tear or tendinopathy that hasn't healed with rest and PT
  • Active and motivated, willing to follow a rehab plan
  • Hoping to avoid or delay surgery in a borderline case
Evaluation

What evaluation includes

Your first visit gives you a diagnosis, an honest take on whether biologics fit, and a clear cost picture.

  • Detailed history: what you've already tried, what hasn't worked
  • Hands-on exam of the affected joint or tendon
  • On-site imaging (X-ray, ultrasound) at most offices
  • Plain-English review of the evidence for your specific condition
  • Out-of-pocket cost quoted before any biologic treatment

ImportantRegenerative medicine is not appropriate for active infections, certain cancers, bleeding disorders, or end-stage (bone-on-bone) arthritis. We'll screen for these at your visit.

Your regenerative medicine recovery roadmap.

Biologics don't work overnight. Healing is driven by your body's response over weeks; patience and a coordinated rehab plan matter as much as the injection itself.

  1. Days 0 to 14

    Right after injection

    In the first two weeks we protect the treated tissue and let the inflammatory healing cascade get to work.

    • Relative rest of the treated area for 24 to 72 hours
    • Avoid NSAIDs: they can blunt the healing response
    • Acetaminophen and ice for soreness as needed
    • Gentle range-of-motion within your provider's guidance
  2. Weeks 2 to 8

    Loading and rehabilitation

    Progressive loading is what turns a biologic injection into real, durable tissue repair.

    • Targeted physical therapy with your in-network provider
    • Progressive strengthening of the involved tendon or joint
    • Activity advanced as symptoms allow
    • Follow-up visit to check progress and decide on a second treatment
  3. Months 2 to 6

    Long-term response

    Most patients who respond to biologics see continued improvement through three to six months. We track outcomes honestly.

    • Return-to-activity plan with measured benchmarks
    • Decision point at 3 months: meaningful improvement or not
    • Second injection considered for partial responders
    • Honest re-evaluation if biologics didn't move the needle
Risks & considerations

What to weigh before you decide.

Biologic therapy is generally safe when delivered by experienced providers, but it's not risk-free, and the bigger consideration for most patients is cost-vs-likely-benefit.

General

General considerations

Any injection carries a small risk set. Because PRP and BMAC use your own blood or bone marrow, allergic reaction is essentially nil.

  • Soreness at the injection site for 24 to 72 hours (common)
  • Bruising or swelling at the draw or injection site
  • Rare risk of infection (mitigated by sterile technique)
  • Vasovagal response (lightheadedness) during the procedure
Specific

Regenerative medicine considerations

These are the questions every patient should ask before paying out of pocket for a biologic.

  • Response rates vary; not everyone improves
  • Most regenerative therapies are not covered by insurance
  • BMAC / 'stem cell' marketing often outpaces the evidence; be skeptical
  • Biologics cannot reverse advanced arthritis or heal fully torn ligaments
  • May delay, but not always replace, the need for surgery

Meet the regenerative medicine specialists at LAOSS.

Our regenerative medicine program is led by board-certified orthopedic, sports medicine, and pain management physicians who use biologics as one tool among many, not as a marketing pitch. Each provider has been trained in ultrasound-guided injection technique and stays current with the orthopedic literature on what's working and what isn't. We'll give you a straight read on whether a biologic is the right next step in your care, and we'll never push a treatment we don't believe in.

Meet your regenerative medicine specialists.

View all providers
Compare up to 34 providers
  • Accepting new patients

    Kevin Pelton, MD

    Orthopedic Surgeon · Founder

    • East Los Angeles
    • Encino
    • Valencia
  • Accepting new patients

    Jayson Lian, MD

    Sports Medicine Surgeon

    • Encino
    • Valencia
    • Tarzana
  • Accepting new patients

    Jose Antonio Acosta, MD

    Pain Management & Rehabilitation

    Speaks English and Spanish

    Habla español

    • Glendale
    • Encino
    • Valencia
    • +1 more
  • Accepting new patients

    Raj Desai, MD

    Pain Management & Rehabilitation

    • East Los Angeles

Find care by body area.

Jump to a nearby condition page and compare treatment paths across the body.

Common regenerative medicine questions

  • It depends on the therapy. PRP (platelet-rich plasma) has been used in orthopedics for decades and has reasonable evidence for several specific conditions: tennis elbow, patellar tendinopathy, mild knee osteoarthritis, some rotator cuff problems. BMAC and 'stem cell' therapies for orthopedic conditions are newer, have more limited high-quality evidence, and are generally not FDA-approved for joint indications. We'll tell you honestly where your specific treatment falls on that spectrum.

Don't wait on pain.

Book a visit with a regenerative medicine specialist at any of our eight Los Angeles-area offices.

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21 specialists · 8 offices
Greater Los Angeles
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